BDBM12342 2H-chromen-2-one::CHEMBL6466::Coumarin

SMILES O=c1ccc2ccccc2o1

InChI Key InChIKey=ZYGHJZDHTFUPRJ-UHFFFAOYSA-N

Data  56 KI  17 IC50

PDB links: 10 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 12342   

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human CA1 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM12342(2H-chromen-2-one | CHEMBL6466 | Coumarin)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed